HIV-1 diversity and the implementation of integrase strand-transfer inhibitors as part of combination antiretroviral therapy

dc.contributor.authorCloete, Ruben
dc.contributor.authorMikasi, Sello Given
dc.contributor.authorIkomey, George Mondinde
dc.date.accessioned2021-01-08T09:21:35Z
dc.date.available2021-01-08T09:21:35Z
dc.date.issued2020
dc.description.abstract: The integrase (IN) strand-transfer inhibitor (InSTI) dolutegravir (DTG) is now recommended by the World Health Organization as part of salvage and/or first-line combination antiretroviral therapy (cART).[1] DTG has a high genetic barrier against developing resistance and is effective against all strains that previously exhibited resistance-associated mutations (RAMs) against other cART regimens.[2] Recommendations to use DTG were delayed owing to preliminary findings from Botswana that indicated potential safety concerns in pregnancy, with a small increased risk of neural tube defects.[3] Studies that investigated the safety and efficacy of DTG now support its use in all populations, including pregnant women and those of childbearing potentialen_US
dc.identifier.citationCloete, R. et al. (2020). HIV-1 diversity and the implementation of integrase strand-transfer inhibitors as part of combination antiretroviral therapy. South African Medical Journal, 110(9), 827en_US
dc.identifier.issn2078-5135
dc.identifier.uri10.7196/SAMJ.2020.v110i9.14848
dc.identifier.urihttp://hdl.handle.net/10566/5617
dc.language.isoenen_US
dc.publisherSAMAen_US
dc.subjectHIV-1en_US
dc.subjectAfricaen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectDrug safetyen_US
dc.subjectPregnant womenen_US
dc.titleHIV-1 diversity and the implementation of integrase strand-transfer inhibitors as part of combination antiretroviral therapyen_US
dc.typeArticleen_US

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