The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages
| dc.contributor.author | Martin, Darren P | |
| dc.contributor.author | Weaver, Steven | |
| dc.contributor.author | Tegally, Houriiyah | |
| dc.date.accessioned | 2021-11-15T10:22:51Z | |
| dc.date.available | 2021-11-15T10:22:51Z | |
| dc.date.issued | 2021-09 | |
| dc.description.abstract | The independent emergence late in 2020 of the B.1.1.7, B.1.351, and P.1 lineages of SARS-CoV-2 prompted renewed concerns about the evolutionary capacity of this virus to overcome public health interventions and rising population immunity. Here, by examining patterns of synonymous and non-synonymous mutations that have accumulated in SARS-CoV-2 genomes since the pandemic began, we find that the emergence of these three ‘‘501Y lineages’’ coincided with a major global shift in the selective forces acting on various SARS-CoV-2 genes. Following their emergence, the adaptive evolution of 501Y lineage viruses has involved repeated selectively favored convergent mutations at 35 genome sites, mutations we refer to as the 501Y meta-signature. The ongoing convergence of viruses in many other lineages on this meta-signature suggests that it includes multiple mutation combinations capable of promoting the persistence of diverse SARS-CoV-2 lineages in the face of mounting host immune recognition. | en_US |
| dc.identifier.citation | D.P Martin et al. (2021) . The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages. Cell, 184(20), 5189–5200.e7. https://doi.org/10.1016/j.cell.2021.09.003 | en_US |
| dc.identifier.uri | https://doi.org/10.1016/j.cell.2021.09.003 | |
| dc.identifier.uri | http://hdl.handle.net/10566/7011 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.subject | SARS-CoV-2 | en_US |
| dc.subject | N501Y lineages | en_US |
| dc.subject | Viruses | en_US |
| dc.subject | Public health | en_US |
| dc.title | The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages | en_US |
| dc.type | Article | en_US |