Novel genomic biomarkers for pediatric and adult acute myeloid leukemia

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dc.contributor.advisorBendou, Hocine
dc.contributor.advisorEshibona, Nasr O M
dc.date.accessioned2023-08-11T12:54:25Z
dc.date.accessioned2024-05-17T07:57:41Z
dc.date.available2023-08-11T12:54:25Z
dc.date.available2024-05-17T07:57:41Z
dc.date.issued2023
dc.descriptionPhilosophiae Doctor - PhDen_US
dc.description.abstractAcute myeloid leukemia (AML) is a heterogeneous type of blood cancer that affects individuals of all ages. AML patients are categorized into favorable, intermediate, and adverse risks based on patients' genomic features and chromosomal abnormalities. Despite this risk stratification, the progression and outcome of the disease remain highly variable in pediatric and adult patients, which emphasizes the importance of finding more accurate genomic biomarkers studying the gene expression profiling of pediatric and adult AML patients to facilitate and improve the risk stratification of the patients. Consequently, two research aims were proposed to study the prognostic heterogeneity for pediatric and adult AML. In pediatric AML, the research project was set to identify a genetic signature related to patients with FLT3-ITD mutation and poor survival. While for adult AML, this study focused on establishing a genetic signature predictive of prognosis with the ability to accurately reclassify the risk of AML intermediate group.en_US
dc.identifier.urihttps://hdl.handle.net/10566/15261
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectLeukemiaen_US
dc.subjectAcute myeloid leukemiaen_US
dc.subjectCytogenetics of leukemiaen_US
dc.subjectBioinformaticsen_US
dc.subjectPediatric and adult patientsen_US
dc.titleNovel genomic biomarkers for pediatric and adult acute myeloid leukemiaen_US

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