Efficacy of alcohol containing and alcohol-free chlorhexidine mouth rinse in reducing periodontal disease during prophylactic treatment
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Date
2018
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Abstract
Chlorhexidine has been established as the gold standard against which new
chemical plaque control agents are tested (Jones, 1997). The addition of alcohol
in a chlorhexidine mouthwash had been widely used, however the comparative
efficacy of alcohol free chlorhexidine mouthwash had not fully been explored in
this study, two chlorhexidine mouthwash preparations were tested to evaluate
their comparative efficacy in the treatment of periodontal disease. Aims: To
assess the efficacy of alcohol-free chlorhexidine mouth wash in comparison to
alcohol containing chlorhexidine mouth wash.
Objectives: To determine pre- and post- operative clinical parameters and
microbial load in the management of patients with chronic periodontitis.
Methodology: A double blinded randomised control trial was conducted.
Patients diagnosed with active chronic periodontitis were included in the study
and randomised to either a test (chlorhexidine without alcohol) or control group
(chlorhexidine with alcohol). A total of 50 patients were selected for the study.
Results: The Wilcoxon Signed Rank test was used to test the difference
between the pre-post pair per clinical indicator and Bana-Zyme. The differences
between before and after treatment per indicator were significant at P<0.001 for
respectively Paroex and Peridex. These values demonstrated the difference
between the clinical parameters taken before the treatment and six weeks post
treatment.
Conclusion: Both mouth wash solutions with and without alcohol had proven
to reduce the microbial load as shown by the BANA-Zyme test, with the alcohol
containing solution having been more effective.
Description
Magister Chirurgiae Dentium (MChD)
Keywords
Oral rinse, Chronic periodontitis, Dental plaque, Chlorhexidine, Facultative anaerobes