Development and validation of a pharmacogenomics profiling panel suitable for personalizing metformin therapy
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Date
2019
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Abstract
The burden of non-communicable diseases (NCDs) in South Africa is predicted to
increase substantially in the next decades if the necessary preventative measures are
not taken. The two most common NCDs associated with rapid mortality increase
are diabetes mellitus (DM) and hypertension (HTN). Both of these diseases, i.e DM
and HTN, can be a result of a combination of modifiable risk factors (behavioral)
and non-modifiable risk factors (genetic, physiological, and environmental). New
strategies implemented to manage these diseases should include addressing both
modifiable and non-modifiable risk factors for patients with NCDs. The aim of this
study was to contribute to the reduction of incidence of uncontrolled T2DM among
patients taking metformin as a first-line anti-diabetic drug, through the development
of individualized therapy for this drug. When implemented, this could be one of the
healthcare strategies to address non-modifiable risk factors for patients with T2DM
as an important NCD. The first objective of the study was to explore the prevalence
and risk factors of DM and HTN in South Africa, especially within the
economically disadvantaged population.
Description
>Magister Scientiae - MSc
Keywords
South Africa, Hypertension, Socio-demographics, Glycemic response, Diabetes