Investigating the antimicrobial potential of Thalassomonas actiniarum

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dc.contributor.advisorTrindade, Marla
dc.contributor.advisorvan Zyl, Leonardo
dc.contributor.authorPheiffer, Fazlin
dc.date.accessioned2021-03-18T08:10:16Z
dc.date.accessioned2024-05-09T08:19:34Z
dc.date.available2021-03-18T08:10:16Z
dc.date.available2024-05-09T08:19:34Z
dc.date.issued2020
dc.descriptionPhilosophiae Doctor - PhDen_US
dc.description.abstractThe World Health Organisation predicts that by the year 2050, 10 million people could die annually as a result of infections caused by multidrug resistant bacteria. Individuals with compromised immune systems, caused by underlying disease such as HIV, MTB and COVID-19, are at a greater risk. Antibacterial resistance is a global concern that demands the discovery of novel drugs. Natural products, used since ancient times to treat diseases, are the most successful source of new drug candidates with bioactivities including antibiotic, antifungal, anticancer, antiviral, immunosuppressive, anti-inflammatory and biofilm inhibition. Marine bioprospecting has contributed significantly to the discovery of novel bioactive NPs with unique structures and biological activities, superior to that of compounds from terrestrial origin. Marine invertebrate symbionts are particularly promising sources of marine NPs as the competition between microorganisms associated with invertebrates for space and nutrients is the driving force behind the production of antibiotics, which also constitute pharmaceutically relevant natural products.en_US
dc.identifier.urihttps://hdl.handle.net/10566/13560
dc.language.isoenen_US
dc.publisherUniversity of Western Capeen_US
dc.rights.holderUniversity of Western Capeen_US
dc.subjectBioactive natural productsen_US
dc.subjectMarine natural productsen_US
dc.subjectHeterologous expressionen_US
dc.subjectGenome miningen_US
dc.subjectExopolysaccharidesen_US
dc.titleInvestigating the antimicrobial potential of Thalassomonas actiniarumen_US

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Philosophiae Doctor - PhD (Biotechnology)