Rutin as a potent antioxidant: implications for neurodegenerative disorders

dc.contributor.authorEnogieru, Adaze Bijou
dc.contributor.authorHaylett, William
dc.contributor.authorHiss, Donavon Charles
dc.contributor.authorBardien, Soraya
dc.contributor.authorEkpo, Okobi Eko
dc.date.accessioned2018-07-05T08:14:58Z
dc.date.available2018-07-05T08:14:58Z
dc.date.issued2018
dc.description.abstractA wide range of neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and prion diseases, share common mechanisms such as neuronal loss, apoptosis, mitochondrial dysfunction, oxidative stress, and inflammation. Intervention strategies using plant-derived bioactive compounds have been offered as a form of treatment for these debilitating conditions, as there are currently no remedies to prevent, reverse, or halt the progression of neuronal loss. Rutin, a glycoside of the flavonoid quercetin, is found in many plants and fruits, especially buckwheat, apricots, cherries, grapes, grapefruit, plums, and oranges. Pharmacological studies have reported the beneficial effects of rutin in many disease conditions, and its therapeutic potential in several models of NDs has created considerable excitement. Here, we have summarized the current knowledge on the neuroprotective mechanisms of rutin in various experimental models of NDs. The mechanisms of action reviewed in this article include reduction of proinflammatory cytokines, improved antioxidant enzyme activities, activation of the mitogen-activated protein kinase cascade, downregulation of mRNA expression of PD-linked and proapoptotic genes, upregulation of the ion transport and antiapoptotic genes, and restoration of the activities of mitochondrial complex enzymes. Taken together, these findings suggest that rutin may be a promising neuroprotective compound for the treatment of NDs.en_US
dc.identifier.citationEnogieru, A.B. et al. (2018). Rutin as a potent antioxidant: implications for neurodegenerative disorders. Oxidative Medicine and Cellular Longevity, 2018: 6241017en_US
dc.identifier.issn1942-0900
dc.identifier.urihttps://doi.org/10.1155/2018/6241017
dc.identifier.urihttp://hdl.handle.net/10566/3846
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherHindawi Publishing Corporationen_US
dc.rightsCopyright © 2018 Adaze Bijou Enogieru et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.status.ispeerreviewedTRUE
dc.subjectNeurodegenerative diseases (NDs)en_US
dc.subjectPlant-derived bioactive compoundsen_US
dc.subjectNeuroprotective mechanismsen_US
dc.subjectAntioxidanten_US
dc.titleRutin as a potent antioxidant: implications for neurodegenerative disordersen_US
dc.typeArticleen_US

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