Rutin as a potent antioxidant: implications for neurodegenerative disorders
| dc.contributor.author | Enogieru, Adaze Bijou | |
| dc.contributor.author | Haylett, William | |
| dc.contributor.author | Hiss, Donavon Charles | |
| dc.contributor.author | Bardien, Soraya | |
| dc.contributor.author | Ekpo, Okobi Eko | |
| dc.date.accessioned | 2018-07-05T08:14:58Z | |
| dc.date.available | 2018-07-05T08:14:58Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | A wide range of neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and prion diseases, share common mechanisms such as neuronal loss, apoptosis, mitochondrial dysfunction, oxidative stress, and inflammation. Intervention strategies using plant-derived bioactive compounds have been offered as a form of treatment for these debilitating conditions, as there are currently no remedies to prevent, reverse, or halt the progression of neuronal loss. Rutin, a glycoside of the flavonoid quercetin, is found in many plants and fruits, especially buckwheat, apricots, cherries, grapes, grapefruit, plums, and oranges. Pharmacological studies have reported the beneficial effects of rutin in many disease conditions, and its therapeutic potential in several models of NDs has created considerable excitement. Here, we have summarized the current knowledge on the neuroprotective mechanisms of rutin in various experimental models of NDs. The mechanisms of action reviewed in this article include reduction of proinflammatory cytokines, improved antioxidant enzyme activities, activation of the mitogen-activated protein kinase cascade, downregulation of mRNA expression of PD-linked and proapoptotic genes, upregulation of the ion transport and antiapoptotic genes, and restoration of the activities of mitochondrial complex enzymes. Taken together, these findings suggest that rutin may be a promising neuroprotective compound for the treatment of NDs. | en_US |
| dc.identifier.citation | Enogieru, A.B. et al. (2018). Rutin as a potent antioxidant: implications for neurodegenerative disorders. Oxidative Medicine and Cellular Longevity, 2018: 6241017 | en_US |
| dc.identifier.issn | 1942-0900 | |
| dc.identifier.uri | https://doi.org/10.1155/2018/6241017 | |
| dc.identifier.uri | http://hdl.handle.net/10566/3846 | |
| dc.language.iso | en | en_US |
| dc.privacy.showsubmitter | FALSE | |
| dc.publisher | Hindawi Publishing Corporation | en_US |
| dc.rights | Copyright © 2018 Adaze Bijou Enogieru et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
| dc.status.ispeerreviewed | TRUE | |
| dc.subject | Neurodegenerative diseases (NDs) | en_US |
| dc.subject | Plant-derived bioactive compounds | en_US |
| dc.subject | Neuroprotective mechanisms | en_US |
| dc.subject | Antioxidant | en_US |
| dc.title | Rutin as a potent antioxidant: implications for neurodegenerative disorders | en_US |
| dc.type | Article | en_US |