A guide to molecular characterization of genotype ii African swine fever virus: Essential and alternative genome markers
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Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
African swine fever is a contagious viral disease that has been spreading through Europe
and Asia since its initial report from Georgia in 2007. Due to the large genome size of the causative
agent, the African swine fever virus (ASFV), the molecular epidemiology, and virus evolution are
analyzed by employing different markers. Most of these markers originate from single nucleotide
polymorphisms or disparities in the copy number of tandem repeat sequences observed during the
comparisons of full genome sequences produced from ASFVs isolated during different outbreaks.
Therefore, consistent complete genome sequencing and comparative analysis of the sequence data are
important to add innovative genomic markers that contribute to the delineation of ASFV phylogeny
and molecular epidemiology during active circulation in the field. In this study, the molecular
markers currently employed to assess the genotype II ASFVs circulating in Europe and Asia have
been outlined.
Description
Keywords
Africa, Swine fever virus, Public health, Phylogeny, Biotechnology
Citation
Mazloum, A. et al. (2023). A guide to molecular characterization of genotype ii African swine fever virus: Essential and alternative genome markers. Microorganisms, 11(3), 642. https://doi.org/10.3390/microorganisms11030642