Obesity and metabolic syndrome associated with systemic inflammation and the impact on the male reproductive system

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dc.contributor.authorLeisegang, Kristian
dc.contributor.authorHenkel, Ralf
dc.contributor.authorArgarwal, Ashok
dc.date.accessioned2021-01-20T09:50:50Z
dc.date.available2021-01-20T09:50:50Z
dc.date.issued2019
dc.description.abstractObesity and metabolic syndrome (MetS) are global epidemics, driven by an obe‐sogenic environment. This is mediated by complex underlying pathophysiology, in which chronic inflammation is an important aetiological and mechanistic phenom‐enon. A shift towards a subclinical TH1–lymphocyte mediated innate and chronic in‐flammatory response is well defined in obesity and MetS, demonstrated in multiple systems including visceral adiposity, brain (hypothalamus), muscles, vasculature, liver, pancreas, testes, epididymis, prostate and seminal fluid. Inflammatory cytokines dis‐rupt the hypothalamic‐pituitary‐testes axis and steroidogenesis cascades (hypogon‐adotropic hypogonadism), spermatogenesis (poor semen parameters, including DNA fragmentation and detrimental epigenetic modification) and results in subclinical prostatitis and prostate hyperplasia. This review aims to highlight the role of chronic inflammation in obesity and MetS, cytokines in male reproductive physiology and pathophysiology, the impact on steroidogenesis and spermatogenesis, prostate pa‐thology and erectile dysfunction. Currently, it is recommended that clinical assess‐ment of male infertility and reproductive dysfunction in obese and MetS patients includes inflammation assessment (highly sensitive C‐reactive protein), and appro‐priate advice and therapeutic options are incorporated in the management options. However, the mechanisms and therapeutic options remain poorly understood and require significant interdisciplinary research to identify potential novel therapeutic strategiesen_US
dc.identifier.citationLeisegang, K., Henkel ,R., Argarwal, A. Obesity and metabolic syndrome associated with systemic inflammation and the impact on the male reproductive system .en_US
dc.identifier.urihttp://hdl.handle.net/10566/5696
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltden_US
dc.subjectchronic inflammationen_US
dc.subjectmale infertilityen_US
dc.subjectmetabolic syndromeen_US
dc.subjectobesityen_US
dc.subjectspermatogenesisen_US
dc.subjectsteroidogenesisen_US
dc.titleObesity and metabolic syndrome associated with systemic inflammation and the impact on the male reproductive systemen_US
dc.typeArticleen_US

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Dr. Kristian Leisegang (School of Natural Medicine)