Assessment of thermal and hydrolytic stabilities and aqueous solubility of artesunate for formulation studies

Simple item page
dc.contributor.authorAucamp, M
dc.contributor.authorBezuidenhout, J. W.
dc.contributor.authorStieger, N
dc.contributor.authorLiebenberg, W
dc.contributor.authorHaynes, R. K
dc.date.accessioned2023-03-28T12:45:25Z
dc.date.available2023-03-28T12:45:25Z
dc.date.issued2023
dc.description.abstractFor the purpose of establishing the optimum processing parameters and storage conditions associated with nanolipid formulations of the artemisinin derivative artesunate, it was necessary to evaluate the thermal stability and solubility profiles of artesunate in aqueous solutions at various temperatures and pH. The effect of increased temperature and humidity on artesunate was determined by storing samples of the raw material in a climate chamber for 3 months and analyzing these by an established HPLC methoden_US
dc.identifier.citationBezuidenhout, J.W., Aucamp, M., Stieger, N., Liebenberg, W. and Haynes, R.K., 2023. Assessment of Thermal and Hydrolytic Stabilities and Aqueous Solubility of Artesunate for Formulation Studies. AAPS PharmSciTech, 24(1), p.33.en_US
dc.identifier.urihttps://doi.org/10.1208/s12249-022-02490-8
dc.identifier.urihttp://hdl.handle.net/10566/8687
dc.language.isoenen_US
dc.publisherAAPS PharmSciTechen_US
dc.subjectartesunateen_US
dc.subjectdecompositionen_US
dc.subjectdihydroartemisininen_US
dc.subjectsolubilityen_US
dc.subjectstabilityen_US
dc.titleAssessment of thermal and hydrolytic stabilities and aqueous solubility of artesunate for formulation studiesen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Bezuidenhout_Assessment of Thermal_2023.pdf
Size:
1.5 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Articles (School of Pharmacy)