The validity and reliability of computer-aided semen analyzers in performing semen analysis: a systematic review

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dc.contributor.authorLeisegang, Kristian
dc.contributor.authorAgarwal, Ashok
dc.contributor.authorRenata, Finelli
dc.date.accessioned2021-09-01T03:51:10Z
dc.date.available2021-09-01T03:51:10Z
dc.date.issued2021
dc.description.abstractBackground: Computer-aided sperm analyzers (CASA) are currently used worldwide for semen analysis. However, there are doubts about their reliability to fully substitute the human operator. Therefore, this study aimed to systematically review the current literature comparing results from semen evaluation by both CASA-based and manual approaches. Methods: A systematic screening of the literature was performed based on the PRISMA guidelines and by searching on PubMed, Scopus, and Embase databases. Results: A total of 14 studies were included. Our results showed a high degree of correlation for sperm concentration and motility when analysis was performed either manually or by using a CASA system. However, CASA results showed increased variability in low (<15 million/mL) and high (>60 million/ mL) concentration specimens, while sperm motility assessment was inaccurate in samples with higher concentration or in the presence of non-sperm cells and debris. Morphology results showed the highest level of difference, due to the high amount of heterogeneity seen between the shapes of the spermatozoa either in one sample or across multiple samples from the same subject. Conclusions: Overall, our study suggests CASA systems as a valid alternative for the evaluation of semen parameters in clinical practice, especially for sperm concentration and motility. However, further technological improvements are required before these devices can one day completely replace the human operator. Artificial intelligence-based CASA devices promise to offer higher efficiency of the analysis and improve the reliability of results.en_US
dc.identifier.citationFinelli, Renata & Leisegang, Kristian & Tumallapalli, Samhita & Henkel, Ralf & Agarwal, Ashok. (2021). The validity and reliability of computer-aided semen analyzers in performing semen analysis: a systematic review. Translational Andrology and Urology. 10. 10.21037/tau-21-276.en_US
dc.identifier.uri10.21037/tau-21-276
dc.identifier.urihttp://hdl.handle.net/10566/6578
dc.language.isoenen_US
dc.publisherTranslational Andrology and Urology.en_US
dc.subjectComputer-aideden_US
dc.subjectsperm analyzers (CASA)en_US
dc.subjectcomputer-assisteden_US
dc.subjectsperm analysisen_US
dc.subjectsemen analysis;en_US
dc.subjectsperm concentrationen_US
dc.titleThe validity and reliability of computer-aided semen analyzers in performing semen analysis: a systematic reviewen_US
dc.typeOtheren_US

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