Deletion of IL-4Rα signalling on B cells limits hyperresponsiveness depending on antigen-load.
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
B cells play an important role in allergies through secretion of IgE. Interleukin 4 50 receptor α (IL-4Rα) is key in allergic asthma and regulates type 2 cytokine production, IgE 51 secretion and airway hyperresponsiveness (AHR). IL-4 activation of B cells is essential for 52 class-switching and contributes to the induction of B effector 2 (Be2) cells. The role of Be2 53 cells and signalling via IL-4Rα in B cells is not clearly defined.
Description
Keywords
IL-4Rα, TH2 cells, B cells, germinal centre, T follicular helper cell, B effector 2 cells
Citation
s: Hadebe S, Khumalo J, Mangali S, Mthembu N, Ndlovu H, Scibiorek M,Ngomti A, Kirstein F, Brombacher F, Deletion of IL-4Rα signalling on B cells limits hyperresponsivenessdepending on antigen-load., Journal of Allergy and Clinical Immunology (2021)