Microwave-assisted synthesis of schiff base metal–ligand complexes with copper and nickel centres for electrochemical in vitro sensing of nitric oxide in an aqueous solution
Loading...
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Nitric oxide (NO), the smallest signalling molecule known in the human body, keeps
blood vessels dilated, controls blood pressure, and has numerous other health regulatory effects.
The use of Schiff base complexes incorporated onto electrodes to make electrochemical sensors
has been explored as an effective method for the determination and quantification of nitric oxide
in aqueous solutions. Schiff base ligands were complexed with Cu and Ni metal centres using
the microwave synthesis method to produce metal–ligand complexes with enhanced capabilites
for NO detection. The electrical current generated at the anode is directly proportional to NO
concentrations in the solution through its oxidation to HNO3
. Various characterisation techniques
were implemented to verify the integrity of each step of metal–ligand synthesis as well as the final
product produced, using FT-IR, UV-VIS, and TGA.
Description
Keywords
Electrochemical sensor, Nitric oxide, Cytochrome C, Chemistry, Copper
Citation
Moeketse, T. N. et al. (2022). Microwave-assisted synthesis of schiff base metal–ligand complexes with copper and nickel centres for electrochemical in vitro sensing of nitric oxide in an aqueous solution. Chemosensors , 10(5),175. https://doi.org/10.3390/chemosensors10050175