Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care

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dc.contributor.authorDarius, Riziki
dc.contributor.authorSibuyi, Nicole Remaliah Samantha
dc.contributor.authorOluwaseun, Fadaka Adewale
dc.date.accessioned2021-09-01T06:45:44Z
dc.date.available2021-09-01T06:45:44Z
dc.date.issued2021
dc.description.abstractThe transmission of Tuberculosis (TB) is very rapid and the burden it places on health care systems is felt globally. The effective management and prevention of this disease requires that it is detected early. Current TB diagnostic approaches, such as the culture, sputum smear, skin tuberculin, and molecular tests are time-consuming, and some are unaffordable for low-income countries. Rapid tests for disease biomarker detection are mostly based on immunological assays that use antibodies which are costly to produce, have low sensitivity and stability. Aptamers can replace antibodies in these diagnostic tests for the development of new rapid tests that are more cost effective; more stable at high temperatures and therefore have a better shelf life; do not have batch-to-batch variations, and thus more consistently bind to a specific target with similar or higher specificity and selectivity and are therefore more reliable. Advancements in TB research, in particular the application of proteomics to identify TB specific biomarkers, led to the identification of a number of biomarker proteins, that can be used to develop aptamer-based diagnostic assays able to screen individuals at the point-of-care (POC) more efficiently in resource-limited settings.en_US
dc.identifier.citationDarius, Riziki & Sibuyi, Nicole & Dube, Phumuzile & Adewale, Oluwaseun, Fadaka & Cloete, Ruben & Onani, Martin & Madiehe, Abram & Meyer, Mervin. (2021). Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care. Diagnostics. 11. 1352. 10.3390/diagnostics11081352.en_US
dc.identifier.uri10.3390/diagnostics11081352.
dc.identifier.urihttp://hdl.handle.net/10566/6583
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjecttuberculosisen_US
dc.subjectaptamersen_US
dc.subjectdiagnosticsen_US
dc.subjectlateral flow assaysen_US
dc.subjectpoint-of-careen_US
dc.subjectbiomarkersen_US
dc.titleAptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Careen_US
dc.typeArticleen_US

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