Antibacterial activities of bacteria isolated from the marine sponges Isodictya compressa and Higginsia bidentifera collected from Algoa Bay, South Africa
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI AG
Abstract
Due to the rise inmulti-drug resistant pathogens and other diseases, there is renewed interest
in marine sponge endosymbionts as a rich source of natural products (NPs). The South African marine
environment is rich in marine biota that remains largely unexplored and may represent an important
source for the discovery of novel NPs.We first investigated the bacterial diversity associated with five
South African marine sponges, whose microbial populations had not previously been investigated,
and select the two sponges (Isodictya compressa and Higginsia bidentifera) with highest species richness
to culture bacteria. By employing 33 different growth conditions 415 sponge-associated bacterial
isolates were cultured and screened for antibacterial activity. Thirty-five isolates showed antibacterial
activity, twelve of which exhibited activity against the multi-drug resistant Escherichia coli 1699,
implying that some of the bioactive compounds could be novel. Genome sequencing of two of these
isolates confirmed that they harbour uncharacterized biosynthetic pathways that may encode novel
chemical structures.
Description
Keywords
Isodictya compressa, Higginsia bidentifera, Natural products, Marine sponge, Antimicrobial
Citation
Matobole, R. M. (2017). Antibacterial activities of bacteria isolated from the
marine sponges Isodictya compressa and Higginsia bidentifera collected from Algoa Bay, South Africa. Marine Drugs, 15(2): 47