Gold nanoparticulate modified thioglycolic acid (tga) phenotype nanobiosensor for tuberculosis drugs

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dc.contributor.advisorAjayi, Rachel F.
dc.contributor.authorTshobeni, Ziyanda Zamaswazi
dc.date.accessioned2022-05-17T07:17:52Z
dc.date.accessioned2024-05-09T10:49:58Z
dc.date.available2024-05-09T10:49:58Z
dc.date.issued2022
dc.description>Magister Scientiae - MScen_US
dc.description.abstractTuberculosis (TB) carries on being a major global health issue and it is responsible for 1.5 million disease-related mortality in 2020, according to the World Health organisation (WHO). One of the major causes of death among TB patients is the development of drug-resistant TB due to the inappropriate dosage of the treatment drug, non-adherence to the prescribed regimen or using low quality medication. A fast and reliable detection method (such as biosensing) for real-time determination of a patient’s TB drug metabolism profile is therefore very important for ensuring appropriate prescription. In this study, an electrochemical nanobiosensor for the determination of the TB drug, isoniazid also known as isonicotinic acid hydrazide (INH) was developed. It consists of a cytochrome P450-2E1 (CYP2E1) isoenzyme covalently attached on a gold electrode (screen printed or disk) that was functionalized with thioglycolic acid-capped gold nanoparticle (TGA-AuNP), which was green-synthesized with banana peel extract (BPE) as the reducing agent.en_US
dc.description.embargo2025
dc.identifier.urihttps://hdl.handle.net/10566/14444
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectGreen synthesisen_US
dc.subjectGold nanoparticleen_US
dc.subjectThioglycolic aciden_US
dc.subjectTuberculosisen_US
dc.subjectDrugsen_US
dc.titleGold nanoparticulate modified thioglycolic acid (tga) phenotype nanobiosensor for tuberculosis drugsen_US

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