Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders

dc.contributor.authorCuttler, Katelyn
dc.contributor.authorHassan, Maryam
dc.contributor.authorCarr, Jonathan
dc.date.accessioned2021-11-23T11:43:50Z
dc.date.available2021-11-23T11:43:50Z
dc.date.issued2021
dc.description.abstractSynaptopathies are brain disorders characterized by dysfunctional synapses, which are specialized junctions between neurons that are essential for the transmission of information. Synaptic dysfunction can occur due to mutations that alter the structure and function of synaptic components or abnormal expression levels of a synaptic protein. One class of synaptic proteins that are essential to their biology are cell adhesion proteins that connect the pre- and post-synaptic compartments. Neurexins are one type of synaptic cell adhesion molecule that have, recently, gained more pathological interest. Variants in both neurexins and their common binding partners, neuroligins, have been associated with several neuropsychiatric disorders. In this review, we summarize some of the key physiological functions of the neurexin protein family and the protein networks they are involved in. Furthermore, examination of published literature has implicated neurexins in both neuropsychiatric and neurodegenerative disorders.en_US
dc.identifier.citationCuttler, K. et al. (2021). Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders. Open biology, 11(10), 210091.https://doi.org/10.1098/rsob.210091en_US
dc.identifier.issn2046-2441
dc.identifier.urihttps://doi.org/10.1098/rsob.210091
dc.identifier.urihttp://hdl.handle.net/10566/7035
dc.language.isoenen_US
dc.publisherThe Royal Societyen_US
dc.subjectNeurexinen_US
dc.subjectNeuroliginen_US
dc.subjectNeurodegenerative disordersen_US
dc.subjectProtein interactionsen_US
dc.subjectNeuropsychiatric disordersen_US
dc.titleEmerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disordersen_US
dc.typeArticleen_US

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