Are claudin-5 tight-junction proteins in the blood-brain barrier porous?

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dc.contributor.authorFisher, David W.
dc.contributor.authorMentor, Shireen
dc.date.accessioned2020-12-10T10:07:17Z
dc.date.available2020-12-10T10:07:17Z
dc.date.issued2020
dc.description.abstractThe capillaries of the brain are particularly special, as they are not simply conduits for blood, but are primarily responsible to ensure that the neurons function in a strictly regulated homeostatic interstitium. Brain endothelial cells (BECs) express a plethora of ion channels on its luminal and abluminal surfaces, namely: potassium (K+ ) channels (i.e., Kir2 and Kv1), chloride (Cl–)/bicarbonate (HCO3–) channels, as well as a number of ion-solute exchangers (Redzic et al., 2011). These channels essentially prioritize vectorial transendothelial transport, especially for the regulation of K+ flux across the blood-brain barrier (BBB) (Redzic et al., 2011). The differences between the K+ concentration of the brain interstitium and plasma is only 2 mM to 4 mM, but the maintenance of this ionic concentration difference provides a constancy for the neuronal resting membrane potential, their associated firing thresholds and the preservation of a constant level of neuronal excitability.en_US
dc.identifier.citationFisher , D., & Mentor ,S. (2020). Are claudin-5 tight-junction proteins in the blood-brain barrier porous? .Neural Regen Res, 15(10),1838-1839en_US
dc.identifier.issn1876-7958
dc.identifier.uri10.4103/1673-5374.280308
dc.identifier.urihttp://hdl.handle.net/10566/5492
dc.language.isoenen_US
dc.publisherWolters Kluwer Healthen_US
dc.subjectClaudin-5en_US
dc.subjectBlood-brainen_US
dc.subjectNeuronalen_US
dc.subjectTJ pore-forming proteinsen_US
dc.subjectThe brain capillaryen_US
dc.titleAre claudin-5 tight-junction proteins in the blood-brain barrier porous?en_US
dc.typeArticleen_US

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