Anticancer and drug-sensitizing activities of gold nanoparticles synthesized from cyclopia genistoides (honeybush) extracts

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dc.contributor.authorSharma, Jyoti Rajan
dc.contributor.authorSibuyi, Nicole Remaliah Samantha
dc.contributor.authorFadaka, Adewale Oluwaseun
dc.date.accessioned2023-04-20T09:56:56Z
dc.date.available2023-04-20T09:56:56Z
dc.date.issued2023
dc.description.abstractSynthesis of gold nanoparticles (AuNPs) using phytochemicals has become tremendously prominent in biomedical applications because of its enhanced bioactivity and biocompatibility. In this study, water extracts from the leaves of Cyclopia genistoides (C. genistoides), commonly known as honeybush (HB), were used to synthesize honeybush gold nanoparticles (HB-AuNPs). The HB water extracts (HBE) served as both reducing and capping agents in the synthesis of HB-AuNPs. The HB-AuNPs were characterized by UV–Vis spectrophotometry, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The cytotoxicity and apoptotic effects of the HBE and HB-AuNPs, alone and in combination with doxorubicin (Dox), were examined against various human cell lines. Spherical-shaped HB-AuNPs with a hydrodynamic diameter range of 63 to 121 nm were produced.en_US
dc.identifier.citationSharma, J. R. et al. (2023). Anticancer and drug-sensitizing activities of gold nanoparticles synthesized from cyclopia genistoides (honeybush) extracts. Applied Sciences, 13(6), 3973. https://doi.org/10.3390/app13063973en_US
dc.identifier.issn2076-3417
dc.identifier.urihttps://doi.org/10.3390/app13063973
dc.identifier.urihttp://hdl.handle.net/10566/8842
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectGold nanoparticlesen_US
dc.subjectBiotechnologyen_US
dc.subjectGreen synthesisen_US
dc.subjectMedicinal plantsen_US
dc.subjectPhytotherapyen_US
dc.titleAnticancer and drug-sensitizing activities of gold nanoparticles synthesized from cyclopia genistoides (honeybush) extractsen_US
dc.typeArticleen_US

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