PZQ Therapy: How close are we in the development of effective alternative anti-schistosomal drugs?

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dc.contributor.authorAruleba, Raphael Taiwo
dc.contributor.authorAdekiya, Tayo Alex
dc.contributor.authorPretorius, Ashley
dc.date.accessioned2021-07-09T09:51:11Z
dc.date.available2021-07-09T09:51:11Z
dc.date.issued2019
dc.description.abstractToday schistosomiasis, caused mainly by the three major schistosome species (S. mansoni, S. haematobium and S. japonicum), has for many decades and still continues to be on a rapid and swift rise globally, claiming thousands of lives every year and leaving 800 million people at the risk of infection. Due to the high prevalence of this disease and the steady increase in the infection rates, praziquantel (PZQ) remains the only effective drug against this acute disease although it has no effect on the juvenile schistosome parasite. However, no significant approaches have been made in recent years in the discovery of new or alternative drugs and unfortunately, resistance to this drug has been reported in some parts of the world. Therefore, it is imperative to develop a new drug for this debilitating disease. In this review, a brief history of past, present, and new promising anti-schistosomal drugs is presented.en_US
dc.identifier.citationAruleba, R. T. et al. (2019). PZQ Therapy:How close are we in the development of effective alternative anti-schistosomal drugs ?. Infectious Disorders - Drug Targets, 19(4), 337–349. https://doi.org/10.2174/1871526519666181231153139en_US
dc.identifier.issn2212-3989
dc.identifier.uri10.2174/1871526519666181231153139
dc.identifier.urihttp://hdl.handle.net/10566/6388
dc.language.isoenen_US
dc.publisherBentham Science Publishersen_US
dc.subjectDrugsen_US
dc.subjectPraziquantelen_US
dc.subjectSchistosomiasisen_US
dc.subjectSchistosoma mansonien_US
dc.subjectSchistosoma haematobiumen_US
dc.subjectSchistosomeen_US
dc.titlePZQ Therapy: How close are we in the development of effective alternative anti-schistosomal drugs?en_US
dc.typeArticleen_US

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