Amount of cycloserine emanating from terizidone metabolism and relationship with hepatic function in patients with drug resistant tuberculosis
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Date
2019
Authors
Journal Title
Journal ISSN
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Publisher
Springer
Abstract
The dosing of cycloserine and terizidone is the same, as both drugs are considered equivalent
or used interchangeably. Nevertheless, it is not certain from the literature that these drugs are interchangeable. Therefore,
the amount of cycloserine resulting from the metabolism of terizidone and the relationship with hepatic function were
determined. This prospective clinical study involved 39 patients with drug-resistant tuberculosis admitted for an intensive
phase of treatment. Cycloserine pharmacokinetic parameters for individual patients, like area under the curve (AUC), clearance (CLm/F), peak concentration (Cmax) and trough concentration (Cmin), were calculated from a previously validated joint
population pharmacokinetic model of terizidone and cycloserine. Correlation and regression analyses were performed for
pharmacokinetic parameters and unconjugated bilirubin (UB), conjugated bilirubin (CB), albumin, the ratio of aspartate
transaminase to alanine aminotransferase (AST/ALT), or binding afnity of UB to albumin (Kaf), using R statistical software
version 3.5.3.
Description
Keywords
Public health, Tuberculosis, Patients, Drugs, Pharmacy
Citation
Mulubwa, M., & Mugabo, P. (2019). Amount of cycloserine emanating from terizidone metabolism and relationship with hepatic function in patients with drug resistant Tuberculosis. Drugs in R&D, 19 (3) , 289-296. https://doi.org/10.1007/s40268-019-00281-4