Database for exploration of functional context of genes implicated in ovarian cancer

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dc.contributor.authorKaur, Mandeer
dc.contributor.authorRadovanovic, Aleksander
dc.contributor.authorEssack, Magbubah
dc.contributor.authorSchaefer, Ulf
dc.contributor.authorMaqungo, Monique
dc.contributor.authorKibler, Tracey
dc.contributor.authorSchmeier, Sebastian
dc.contributor.authorChristoffels, Alan
dc.contributor.authorNarasimhan, Kothandaraman
dc.contributor.authorChoolani, Mahesh
dc.contributor.authorBajic, Vladimir B.
dc.date.accessioned2015-10-28T14:21:05Z
dc.date.available2015-10-28T14:21:05Z
dc.date.issued2009
dc.description.abstractOvarian cancer (OC) is becoming the most common gynecological cancer in developed countries and the most lethal gynecological malignancy. It is also the fifth leading cause of all cancer-related deaths in women. The identification of diagnostic biomarkers and development of early detection techniques for OC largely depends on the understanding of the complex functionality and regulation of genes involved in this disease. Unfortunately, information about these OC genes is scattered throughout the literature and various databases making extraction of relevant functional information a complex task. To reduce this problem, we have developed a database dedicated to OC genes to support exploration of functional characterization and analysis of biological processes related to OC. The database contains general information about OC genes, enriched with the results of transcription regulation sequence analysis and with relevant text mining to provide insights into associations of the OC genes with other genes, metabolites, pathways and nuclear proteins. Overall, it enables exploration of relevant information for OC genes from multiple angles, making it a unique resource for OC and will serve as a useful complement to the existing public resources for those interested in OC genetics.en_US
dc.description.sponsorshipNational Bioinformatics grants National Research foundation DST/NRF Research Chairen_US
dc.identifier.urihttp://hdl.handle.net/10566/1931
dc.language.isoenen_US
dc.privacy.showsubmitterfalse
dc.publisherOxford Journalsen_US
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.source.urihttp://dx.doi.org/10.1093/nar/gkn593
dc.status.ispeerreviewedfalse
dc.subjectOvarian canceren_US
dc.subjectDatabaseen_US
dc.subjectFunctional characterizationen_US
dc.titleDatabase for exploration of functional context of genes implicated in ovarian canceren_US
dc.typeArticleen_US

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