Whole-genome sequencing of African swine fever virus from wild boars in the Kaliningrad region reveals unique and distinguishing genomic mutations

Loading...
Thumbnail Image

Date

2023

Journal Title

Journal ISSN

Volume Title

Publisher

Frontiers Media

Abstract

Since the first report of outbreaks of African swine fever (ASF) in Georgia in 2007, the disease has expanded into Europe, Russia, and Asia, spreading rapidly via contact with infected animals including domestic pigs and wild boars. The vast expansion of this Genotype II African swine fever virus (ASFV) across wide-ranging territories and hosts inevitably led to the acquisition of novel mutations. These mutations could be used to track the molecular epidemiology of ASFV, provided that they are unique to strains restricted within a certain area. Whilst whole-genome sequencing remains the gold standard for examining evolutionary changes, sequencing of a single locus with significant variation and resolution power could be used as a rapid and cost-e􀀀ective alternative to characterize multiple isolates from a single or related outbreak.

Description

Keywords

Biotechnology, Public health, Swine fever virus, Africa

Citation

Mazloum, A. et al. (2023). Whole-genome sequencing of African swine fever virus from wild boars in the Kaliningrad region reveals unique and distinguishing genomic mutations. Frontiers in Veterinary Science, 9. https://doi.org/10.3389/fvets.2022.1019808