Synthesis, characterization, and molecular docking of novel 4-Aminoquinolines and Salicylaldimine complexes: evaluation as antimalarial and antitumor agents
Loading...
Date
2016
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Abstract
Malaria remains a major global health problem and to date, hundreds of thousands of people
die as a result of this disease every year. Malaria has been able to adapt and rebound despite
various efforts made to combat the disease. The decrease in efficacy of many front-line drugs
against malaria, due to increased resistance, prompts investigation into obtaining effective
compounds that are able to overcome this resistance. This study investigated the synthesis,
characterisation and biological evaluation of new quinoline (as antimalarial agents) as well as
non-quinoline (as antitumor agents) based compounds.
Description
Philosophiae Doctor - PhD (Chemistry)