Covid-19 among adults living with HIV: Correlates of mortality among public sector healthcare users in Western Cape, South Africa

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dc.contributor.authorKassanjee, Reshma
dc.contributor.authorDavies, Mary-Ann
dc.contributor.authorTiffin, Nicki
dc.date.accessioned2023-07-17T10:57:52Z
dc.date.available2023-07-17T10:57:52Z
dc.date.issued2023
dc.description.abstractIntroduction: While a large proportion of people with HIV (PWH) have experienced SARS-CoV-2 infections, there is uncertainty about the role of HIV disease severity on COVID-19 outcomes, especially in lower-income settings. We studied the association of mortality with characteristics of HIV severity and management, and vaccination, among adult PWH. Methods: We analysed observational cohort data on all PWH aged ≥15 years experiencing a diagnosed SARS-CoV-2 infection (until March 2022), who accessed public sector healthcare in the Western Cape province of South Africa. Logistic regression was used to study the association of mortality with evidence of antiretroviral therapy (ART) collection, time since first HIV evidence, CD4 cell count, viral load (among those with evidence of ART collection) and COVID-19 vaccination, adjusting for demographic characteristics, comorbidities, admission pressure, location and time period. Results: Mortality occurred in 5.7% (95% CI: 5.3,6.0) of 17,831 first-diagnosed infections. Higher mortality was associated with lower recent CD4, no evidence of ART collection, high or unknown recent viral load and recent first HIV evidence, differentially by age. Vaccination was protective. The burden of comorbidities was high, and tuberculosis (especially more recent episodes of tuberculosis), chronic kidney disease, diabetes and hypertension were associated with higher mortality, more strongly in younger adults.en_US
dc.identifier.citationKassanjee, R. et al. (2023). Covid-19 among adults living with HIV: Correlates of mortality among public sector healthcare users in Western Cape, South Africa. Journal of the International AIDS Society, 26(6), e26104. 10.1002/jia2.26104en_US
dc.identifier.issn1758-2652
dc.identifier.uri10.1002/jia2.26104
dc.identifier.urihttp://hdl.handle.net/10566/9208
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectCovid-19en_US
dc.subjectPublic healthen_US
dc.subjectPublic sectoren_US
dc.subjectWestern Capeen_US
dc.subjectStatisticsen_US
dc.subjectBioinformaticsen_US
dc.titleCovid-19 among adults living with HIV: Correlates of mortality among public sector healthcare users in Western Cape, South Africaen_US
dc.typeArticleen_US

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