Characterization and Cradiovascular Effects of (13S)-9α,13α-epoxylabda-6β(19),15(14)diol dilactone, a Diterpenoid Isolated from Leonotis leonurus
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Date
2008
Journal Title
Journal ISSN
Volume Title
Publisher
South African Chemical Institute
Abstract
A new diterpenoid, (13S)-9 ,13 -epoxylabda-6 (19),15(14)diol dilactone (1), was isolated from Leonotis leonurus and the structure determined via NMR analysis. The compound causes significant changes in blood pressure of anaesthetized normotensive rats and exhibits a negative chronotropic effect.
Description
Keywords
Leonotis leonurus, Diterpenoid, NMR analysis, Chronotropic effect
Citation
Obikezea, K.C., et al. (2008). Characterization and Cradiovascular Effects of (13S)-9α,13α-epoxylabda-6β(19),15(14)diol dilactone, a Diterpenoid Isolated from Leonotis leonurus. South African Journal of Chemistry, 61: 119-122