Analyses of sequence divergence using completely sequenced genomes

dc.contributor.advisorSeoighe, Cathal
dc.contributor.authorNembaware, Victoria P.
dc.date.accessioned2023-06-15T13:41:24Z
dc.date.accessioned2024-05-17T07:20:03Z
dc.date.available2023-06-15T13:41:24Z
dc.date.available2024-05-17T07:20:03Z
dc.date.issued2003
dc.description>Magister Scientiae - MScen_US
dc.description.abstractUsing the complete genome, Saccharomyces cerevisiae, which duplicated after its speciation fuom Kluyveromyces lactics, a dataset of 119 putative S. cerevisiae - K. lactis ortholog-pairs was constructed. S. cerevisiae paralogous pairs that are likely to have duplicated during the whole genome duplication of S. cerevisiae were obtained and the approach taken in our previous work (Nembaware et al., 20OZ), was repeated to test whether the presence of a paralogue in S. cerevisiae had an effect on the rate of sequence divergence of the 119 pairs of orthologous genes. We found, however, that substitutions at synonymous sites had reached saturation and this prevented us from being able to repeat the previous finding with S. cerevistae and K. lactis . From this study a publicly available web-server (http://hamlyn.sanbi.ac.zal-victoria) that automates the calculation of Ka:Ks values given a pairs homologous CDS sequences is presented.en_US
dc.identifier.urihttps://hdl.handle.net/10566/15219
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectDivergenceen_US
dc.subjectS. cerevesiaeen_US
dc.subjectBLASTen_US
dc.subjectK. lacticsen_US
dc.titleAnalyses of sequence divergence using completely sequenced genomesen_US

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