Cellular and molecular targets of waterbuck repellent blend odors in antennae of glossina fuscipes fuscipes newstead, 1910
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Media S.A.
Abstract
Insects that transmit many of the world’s deadliest animal diseases, for instance
trypanosomosis, find their suitable hosts and avoid non-preferred hosts mostly through
olfactory cues. The waterbuck repellent blend (WRB) comprising geranylacetone,
guaiacol, pentanoic acid, and d-octalactone derived from waterbuck skin odor is a
repellent to some savannah-adapted tsetse flies and reduces trap catches of riverine
species. However, the cellular and molecular mechanisms associated with detection
and coding of the repellent odors remain to be elucidated. Here, we demonstrated that
WRB inhibited blood feeding in both Glossina pallidipes Austen, 1903 and Glossina
fuscipes fuscipes Newstead, 1910. Using the DREAM (Deorphanization of Receptors
based on Expression Alterations in odorant receptor mRNA levels) technique, combined
with ortholog comparison and molecular docking, we predicted the putative odorant
receptors (ORs) for the WRB in G. f. fuscipes, a non-model insect.
Description
Keywords
Behavior, Molecular docking, Molecular dynamics, Olfaction, Physiology
Citation
Diallo, S. et al. (2020). Cellular and molecular targets of waterbuck repellent blend odors in antennae of glossina fuscipes fuscipes newstead, 1910.Frontiers in Cellular Neuroscience ,14,137