FRAGS: Estimation of coding sequence substitution rates from fragmentary data
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Date
2004
Journal Title
Journal ISSN
Volume Title
Publisher
BMC
Abstract
Rates of substitution in protein-coding sequences can provide important insights into evolutionary processes that are of biomedical and theoretical interest. Increased availability of coding sequence data has enabled researchers to estimate more accurately the coding sequence divergence of pairs of organisms. However the use of different data sources, alignment protocols and methods to estimate substitution rates leads to widely varying estimates of key parameters that define the coding sequence divergence of orthologous genes. Although complete genome sequence data are not available for all organisms, fragmentary sequence data can provide accurate estimates of substitution rates provided that an appropriate and consistent methodology is used and that differences in the estimates obtainable from different data sources are taken into account.
Description
Keywords
Bioinfomatics, Statistics studies, Biomedics, Coding, Orthologous sequence
Citation
Swart, E. C. et al. (2004). FRAGS: Estimation of coding sequence substitution rates from fragmentary data. 5, 8 . https://doi.org/10.1186/1471-2105-5-8