Molecular adaptation mechanisms employed by ethanologenic bacteria in response to lignocellulose-derived inhibitory compounds

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dc.contributor.authorNdimba, Bongani K.
dc.contributor.authorIbraheem, Omodele
dc.date.accessioned2017-02-17T09:19:40Z
dc.date.available2017-02-17T09:19:40Z
dc.date.issued2013
dc.description.abstractCurrent international interest in finding alternative sources of energy to the diminishing supplies of fossil fuels has encouraged research efforts in improving biofuel production technologies. In countries which lack sufficient food, the use of sustainable lignocellulosic feedstocks, for the production of bioethanol, is an attractive option. In the pre-treatment of lignocellulosic feedstocks for ethanol production, various chemicals and/or enzymatic processes are employed. These methods generally result in a range of fermentable sugars, which are subjected to microbial fermentation and distillation to produce bioethanol. However, these methods also produce compounds that are inhibitory to the microbial fermentation process. These compounds include products of sugar dehydration and lignin depolymerisation, such as organic acids, derivatised furaldehydes and phenolic acids. These compounds are known to have a severe negative impact on the ethanologenic microorganisms involved in the fermentation process by compromising the integrity of their cell membranes, inhibiting essential enzymes and negatively interact with their DNA/RNA. It is therefore important to understand the molecular mechanisms of these inhibitions, and the mechanisms by which these microorganisms show increased adaptation to such inhibitors. Presented here is a concise overview of the molecular adaptation mechanisms of ethanologenic bacteria in response to lignocellulose-derived inhibitory compounds. These include general stress response and tolerance mechanisms, which are typically those that maintain intracellular pH homeostasis and cell membrane integrity, activation/regulation of global stress responses and inhibitor substrate-specific degradation pathways. We anticipate that understanding these adaptation responses will be essential in the design of ‘intelligent’ metabolic engineering strategies for the generation of hyper-tolerant fermentation bacteria strains.en_US
dc.description.accreditationISI
dc.identifier.citationNdimba, B. K. et al. (2013). Molecular adaptation mechanisms employed by ethanologenic bacteria in response to lignocellulosederived inhibitory compounds. International Journal of Biological Sciences, 9(6): 598-612en_US
dc.identifier.issn1449-2288
dc.identifier.urihttp://hdl.handle.net/10566/2541
dc.identifier.urihttp://dx.doi.org/10.7150/ijbs.6091
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherIvyspringen_US
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
dc.status.ispeerreviewedTRUE
dc.subjectFermentationen_US
dc.subjectBioethanolen_US
dc.subjectLignocellulosic Inhibitorsen_US
dc.subjectLignocellulolytic materialsen_US
dc.subjectStress Responseen_US
dc.subjectMicrobial Physiologyen_US
dc.subjectPhenolicsen_US
dc.titleMolecular adaptation mechanisms employed by ethanologenic bacteria in response to lignocellulose-derived inhibitory compoundsen_US
dc.typeArticleen_US

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