A quarter century of marine biodiscovery in Algoa bay, South Africa

Simple item page
dc.contributor.authorDavies-Coleman, Michael T
dc.contributor.authorMcPhail, Kerry L
dc.contributor.authorParker-Nance, Shirley
dc.date.accessioned2023-05-22T14:02:21Z
dc.date.available2023-05-22T14:02:21Z
dc.date.issued2023
dc.description.abstractAlgoa Bay, the largest crenulate bay on the south-eastern coast of South Africa, is currently one of the most well-studied marine ecosystems in southern Africa. A plethora of endemic marine invertebrates inhabits the benthic reefs on the western edge of the Bay in close proximity to South Africa’s sixth largest city. Over the past 25 years, South African marine natural products chemists, together with international collaborators from the US National Cancer Institute and other US institutions, have focused their attention on Algoa Bay’s benthic marine invertebrates as a potential source of new anticancer compounds. This review commemorates a quarter of a century of marine biodiscovery in Algoa Bay and presents the structures and bioactivities of 49 new and 36 known specialized metabolites isolated from two molluscs, eight ascidians, and six sponges. Thirty-nine of these compounds were cytotoxic to cancer cells in vitro with 20 exhibiting moderate to potent cytotoxicity. Six other compounds exhibited antimicrobial activity. Foremost among the potential anticancer compounds is mandelalide A (38) from the Algoa Bay ascidian Lissoclinum species.en_US
dc.identifier.citationDavies-Coleman, M.T., McPhail, K.L. and Parker-Nance, S., 2023. A Quarter Century of Marine Biodiscovery in Algoa Bay, South Africa. Journal of Natural Products, 86(3), pp.638-652.en_US
dc.identifier.urihttps://doi.org/10.1021/acs.jnatprod.2c00987
dc.identifier.urihttp://hdl.handle.net/10566/8930
dc.language.isoenen_US
dc.publisherJournal of Natural Productsen_US
dc.subjectAnimalsen_US
dc.subjectAquatic Organismsen_US
dc.subjectBaysen_US
dc.subjectEcosystemen_US
dc.subjectSouth Africaen_US
dc.titleA quarter century of marine biodiscovery in Algoa bay, South Africaen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Davies-Coleman_A Quarter Century_2023.pdf
Size:
8.81 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Articles (Chemistry)