Tunel assay: establishing a sperm dna fragmentation cut-off value for Egyptian infertile men

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dc.contributor.authorHenkel, Ralf
dc.date.accessioned2023-01-11T07:35:37Z
dc.date.available2023-01-11T07:35:37Z
dc.date.issued2019
dc.description.abstractMale factor infertility is responsible for half of all infertility cases. Conventional semen analysis is inadequate to evaluate male fertility. Sperm DNA fragmentation (SDF) test can be done by: direct methods such as Terminal deoxynucleotidyl transferase dUTP Nick-End Labeling (TUNEL) and Comet assay, or indirect like Sperm Chromatin Structure Assay (SCSA) and Sperm Chromatin Dispersion (SCD). TUNEL assay measures both single- and double-strand breaks and is technically less demanding, while SCSA tests for the susceptibility for nuclear DNA denaturation and samples should be sent to the reference lab. Studies showed that a single cut-off value does not fit all.en_US
dc.identifier.citationHassanen, E, Elqusi, K, Zaki, H, Henkel, R, Agarwal, A. TUNEL assay: Establishing a sperm DNA fragmentation cut-off value for Egyptian infertile men. Andrologia. 2019; 51:e13375. https://doi.org/10.1111/and.13375en_US
dc.identifier.issn0303-4569
dc.identifier.urihttp://hdl.handle.net/10566/8255
dc.language.isoen_USen_US
dc.publisherWiley Online Libraryen_US
dc.subjectmale infertilityen_US
dc.subjectSDF cut‐off valueen_US
dc.subjectsperm DNA fragmentationen_US
dc.subjectTunel assayen_US
dc.titleTunel assay: establishing a sperm dna fragmentation cut-off value for Egyptian infertile menen_US
dc.typeArticleen_US

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