Agent in urgent need of clinical practice: corilagin

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dc.contributor.authorWang, Xuejia
dc.contributor.authorFisher, David
dc.contributor.authorPronyuk, Khrystyna
dc.date.accessioned2025-02-14T07:08:52Z
dc.date.available2025-02-14T07:08:52Z
dc.date.issued2023
dc.description.abstractCorilagin is a naturally occurring water-soluble retrogallic acid tannin, which can be ex-tracted from many kinds of plants. Known at present, it is the main effective ingredient of Phyllanthus urinaria L., Geranium wilfordii Maxim., Phyllanthus matsumurae Hayata, and Trifolium repens L. It also exists in Phyllanthus emblica L., Dimocarpus longan Lour., Canarium album (Lour.) Raeusch., and Terminalia chebula Retz. It can participate in a variety of signaling pathways in vivo and has multiple biological activities, including antitumor, anti-microbial, anti-oxidation, anti-inflammation, hepa-toprotective, anti-allergy, anti-proliferation and so on. Given the limited efficacy of first-line treatments for many diseases such as oncology, chronic liver disease, and rheumatic immune system dis-eases, and the potential for adverse effects to outweigh the therapeutic effects, attention is being fo-cused on alternative treatments, and natural plant extracts are a natural target for alternative treat-ments, as natural substances tend to have low toxicity to normal tissues. Some proprietary Chinese medicines containing corilagin have been used in clinical applications, being clinically applied to treat chronic liver disease, viral hepatitis B, rheumatoid arthritis and other diseases. This paper reviews the extraction, determination, distribution and harvesting, pharmacokinetics, biological activity, safety assessment of corilagin and its application in clinical practice.
dc.identifier.citationWang, X., Fisher, D., Pronyuk, K., Dang, Y. and Zhao, L., 2023. Agent in urgent need of clinical practice: Corilagin. Mini reviews in medicinal chemistry, 23(16), pp.1642-1652.
dc.identifier.urihttps://doi.org/10.2174/1389557523666230112110317
dc.identifier.urihttps://hdl.handle.net/10566/19993
dc.language.isoen
dc.publisherBentham Science Publishers
dc.subjectalternative therapy
dc.subjectanti-microbial
dc.subjectanti-proliferation
dc.subjectanti-tumor
dc.subjectsignaling pathway
dc.titleAgent in urgent need of clinical practice: corilagin
dc.typeArticle

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