A comparative ancestry analysis of Y-chromosome DNA haplogroups using high resolution melting
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Date
2018
Authors
Journal Title
Journal ISSN
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Publisher
University of the Western Cape
Abstract
The objective of this study is to deduce paternal ancestry using ancestry
informative single nucleotide polymorphisms (SNPs) by means of High
Resolution Melting (HRM). This was completed by producing a multiplex system
that was designed in a hierarchical manner according to the YSNP tree. This
project mainly focused on African ancestry and was used to infer paternal
ancestral lineages on the Johannesburg Coloured population.
South Africa has a diverse population that has ancestral history from across the
globe. The South African Coloured population is the most admixed population as
it is derived from at least five different population groups: these being Khoisan,
Bantu, Europeans, Indians and Southeast Asians. There have been studies done on
the Western Cape/ Cape Town Coloured populations before but this study focused
on the Johannesburg Coloured population.
Description
>Magister Scientiae - MSc
Keywords
Haplogroups, Y-Chromosome, African ancestry, Multiplex, Coloured population, High resolution melting