The modulating effect of conjugated linoleic acid (CLA) on cancer cell survival in vitro

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dc.contributor.advisorGelderblom, Wentzel
dc.contributor.advisorDe Kock, Maryna
dc.contributor.advisorAbel, Stefan
dc.contributor.authorArendse, Lyle
dc.date.accessioned2015-11-25T14:33:18Z
dc.date.accessioned2024-11-04T13:14:52Z
dc.date.available2015-11-25T14:33:18Z
dc.date.available2024-11-04T13:14:52Z
dc.date.issued2014
dc.descriptionMagister Scientiae (Medical Bioscience) - MSc(MBS)en_US
dc.description.abstractConjugated linoleic acids (CLA) are geometrical and positional isomers of n-6 octadecadenoic acid (linoleic acid, LA, 18:2n-6), which form part of a family of essential polyunsaturated fatty acids (PUFA). There are 28 identified CLA isomers that mostly found in the meat and milk from ruminant animals. CLA has shown to possess a number of health benefits including; reduction in body fat and increased lean body mass, prevention of atherosclerosis, hypertension, increased immune function and in particular the prevention of cancer. The effects of CLA on cancer cell lines will be evaluated to discover the mechanisms that are employed to achieve this great phenomenon on cell growth. The aim of this study was to determine the effect of CLA on various parameters that are essential in the development of cancer cell phenotype. The objectives were to evaluate the effect of CLA on iron-induced lipid peroxidation of microsomes isolated from rat liver cells and in vitro cytotoxicity, cell proliferation and apoptosis in HepG2 hepatocarcinoma cells. The Fatty acid incorporation in HepG2 cells was also assessed.en_US
dc.identifier.urihttps://hdl.handle.net/10566/17203
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectConjugated linoleic aciden_US
dc.subjectCanceren_US
dc.subjectLipid peroxidationen_US
dc.subjectCell cycleen_US
dc.titleThe modulating effect of conjugated linoleic acid (CLA) on cancer cell survival in vitroen_US
dc.typeThesisen_US

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