Obesity and male infertility: Mechanisms and management

dc.contributor.authorLeisegang, K
dc.contributor.authorSengupta, P
dc.contributor.authorAgarwal, A
dc.date.accessioned2021-05-31T11:08:37Z
dc.date.available2021-05-31T11:08:37Z
dc.date.issued2021
dc.description.abstractObesity is considered a global health problem affecting more than a third of the population. Complications of obesity include cardiovascular diseases, type 2 diabetes mellitus, malignancy (including prostatic cancer), neurodegeneration and accelerated ageing. In males, these further include erectile dysfunction, poor semen quality and subclinical prostatitis. Although poorly understood, important mediators of obesity that may influence the male reproductive system include hyperinsulinemia, hyperleptinemia, chronic inflammation and oxidative stress. Obesity is known to disrupt male fertility and the reproduction potential, particularly through alteration in the hypothalamic-pituitary-gonadal axis, disruption of testicular steroidogenesis and metabolic dysregulation, including insulin, cytokines and adipokines. Importantly, obesity and its underlying mediators result in a negative impact on semen parameters, including sperm concentration, motility, viability and normal morphology. Moreover, obesity inhibits chromatin condensation, DNA fragmentation, increases apoptosis and epigenetic changes that can be transferred to the offspring.en_US
dc.identifier.citationHenkel, R. et al. (2021). Obesity and male infertility: Mechanisms and management. Andrologia, 53(1),e13617en_US
dc.identifier.issn03034569
dc.identifier.urihttp://hdl.handle.net/10566/6232
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.subjectMale infertilityen_US
dc.subjectMetabolic syndromeen_US
dc.subjectObesityen_US
dc.subjectSemen qualityen_US
dc.titleObesity and male infertility: Mechanisms and managementen_US
dc.typeArticleen_US

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