Targeting myeloid cells with platelet-derived extracellular vesicles to overcome resistance of immune checkpoint blockade therapy

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dc.contributor.authorDube, Admire
dc.contributor.authorYao, Chenlu
dc.contributor.authorMa, Qingle
dc.date.accessioned2026-01-27T06:59:39Z
dc.date.available2026-01-27T06:59:39Z
dc.date.issued2025
dc.description.abstractImmune checkpoint blockade (ICB) therapy is designed to boost antitumor immune responses, yet it may unintentionally alter the chemokine profile, which can attract suppressive myeloid cells to the tumor, leading to acquired immune resistance. To address this, we developed a platform that targets myeloid cells post-ICB therapy using platelet-derived extracellular vesicles (PEVs). Unlike free drug administration, this system selectively targets anti-PD-L1-treated tumors through the CXCL-CXCR2 axis, effectively redirecting myeloid cells and overcoming ICB resistance. Consequently, mice exhibited robust responses to subsequent ICB therapy cycles, resulting in significantly enhanced tumor clearance and prolonged survival. The PEVs’ targeting capability was also effective in tumors treated with chemotherapy and radiotherapy, suggesting a wide range of potential applications. In summary, PEVs offer a versatile platform for targeted immunomodulation to counteract acquired immune resistance during ICB therapy.
dc.identifier.citationYao, C., Ma, Q., Wang, H., Wu, B., Dai, H., Xu, J., Bai, J., Xu, F., Dube, A. and Wang, C., 2025. Targeting myeloid cells with platelet-derived extracellular vesicles to overcome resistance of immune checkpoint blockade therapy. Biomaterials, 321, p.123336.
dc.identifier.urihttps://doi.org/10.1016/j.biomaterials.2025.123336
dc.identifier.urihttps://hdl.handle.net/10566/21859
dc.language.isoen
dc.publisherElsevier Ltd
dc.subjectAnimals
dc.subjectBlood Platelets
dc.subjectCell Line
dc.subjectTumor
dc.subjectDrug Resistance
dc.titleTargeting myeloid cells with platelet-derived extracellular vesicles to overcome resistance of immune checkpoint blockade therapy
dc.typeArticle

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