Screening of marine bacteria as a source of bioactive secondary metabolites

Simple item page
dc.contributor.advisorTrindade, Marla
dc.contributor.authorMhlongo, Jatro Kulani
dc.date.accessioned2022-03-31T08:25:39Z
dc.date.accessioned2024-05-09T07:46:15Z
dc.date.available2022-03-31T08:25:39Z
dc.date.available2024-05-09T07:46:15Z
dc.date.issued2021
dc.description>Magister Scientiae - MScen_US
dc.description.abstractMarine invertebrate associated (MIA) bacteria are an important source of bioactive secondary metabolites with the potential to address the current anti-microbial resistance crisis experienced globally. Secondary metabolites (SM) have historically yielded several compounds with pharmaceutical applications such as anti-viral, anti-microbial, anti-cancer, anti-inflammatory and anti-parasitic. This study aimed to use bioassay and genomic approaches in the identification of MIA bacteria isolated from South African marine invertebrates as a source of bioactive compounds and the characterisation of the produced SMs using analytical techniques. A total of 23 MIA bacteria were cultured under different conditions (one strain many compounds approach (OSMAC)) to evaluate their ability to produce anti-microbial compounds against a panel of indicator strains namely Escherichia coli 1699, Bacillus cereus ATCC10702, Pseudomonas putida ATCC12633, Mycobacterium aurum A+, Staphylococcus epidermidis ATCC14990, Aspergillus fumigatus MRC and Candida albicans NIOH.en_US
dc.identifier.urihttps://hdl.handle.net/10566/13402
dc.language.isoenen_US
dc.publisherUniversity of Western Capeen_US
dc.rights.holderUniversity of Western Capeen_US
dc.subjectMarine environmenten_US
dc.subjectMarine invertebrateen_US
dc.subjectBacteriaen_US
dc.subjectSecondary metabolitesen_US
dc.subjectAnti-microbialen_US
dc.titleScreening of marine bacteria as a source of bioactive secondary metabolitesen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
mhlongo_m_nsc_2021.pdf
Size:
9.22 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description:
Download

Collections

Magister Scientiae - MSc (Biotechnology)