Trends in Genotypic HIV-1 Antiretroviral resistance between 2006 and 2012 in South African Patients receiving first- and second line antiretroviral treatment regimens
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Date
2013
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Public Library of Science -- PLoS
Public Library of Science -- PLoS
Abstract
South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside
reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We investigated the
associated changes in genotypic drug resistance patterns in patients with first-line ARV treatment failure since the
introduction of these drugs, and protease inhibitor (PI) resistance patterns in patients who received ritonavir-boosted
lopinavir (LPV/r)-containing therapy.
South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We investigated the associated changes in genotypic drug resistance patterns in patients with first-line ARV treatment failure since the introduction of these drugs, and protease inhibitor (PI) resistance patterns in patients who received ritonavir-boosted lopinavir (LPV/r)-containing therapy.
South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We investigated the associated changes in genotypic drug resistance patterns in patients with first-line ARV treatment failure since the introduction of these drugs, and protease inhibitor (PI) resistance patterns in patients who received ritonavir-boosted lopinavir (LPV/r)-containing therapy.
Description
Keywords
Genotypic HIV-1, Antiretroviral resistance, South Africa, Genotypic HIV-1, Antiretroviral resistance, South Africa
Citation
Van Zyl, Gert U. (2013). Trends in genotypic HIV-1 antiretroviral resistance between 2006 and 2012 in South African patients receiving first- and second-line antiretroviral treatment regimens. PLoS ONE 8(6):e67188
Van Zyl, Gert U. (2013). Trends in genotypic HIV-1 antiretroviral resistance between 2006 and 2012 in South African patients receiving first- and second-line antiretroviral treatment regimens. PLoS ONE 8(6):e67188
Van Zyl, Gert U. (2013). Trends in genotypic HIV-1 antiretroviral resistance between 2006 and 2012 in South African patients receiving first- and second-line antiretroviral treatment regimens. PLoS ONE 8(6):e67188