A simple point of care test can indicate the need for periodontal therapy to reduce the risk for adverse pregnancy outcomes in mothers attending antenatal clinics

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dc.contributor.authorTurton, Mervyn Sydney
dc.contributor.authorAfrica, Charlene W.J.
dc.contributor.authorHenkel, Ralf
dc.contributor.authorAfrica, Charlene W.J.
dc.date.accessioned2017-08-18T13:27:04Z
dc.date.available2017-08-18T13:27:04Z
dc.date.issued2017
dc.description.abstractINTRODUCTION: Although the association between periodontal disease (PD) and adverse pregnancy outcomes has gained recognition amongst antenatal healthcare workers, not much has changed in practice to address it. This prospective study tested the hypothesis that BANA (N-benzoyl-DL-arginine- 2-naphthylamide), a diagnostic test for PD, may inform obstetricians and other antenatal healthcare practitioners, of the risk of adverse pregnancy outcomes in mothers attending antenatal clinics. METHODS: At first visit, the presence of suspected periodontopathogens was assessed by BANA testing of dental plaque from 443 mothers attending antenatal clinics in KwaZulu-Natal, South Africa and an association later sought with pregnancy outcomes. The accuracy of BANA to predict adverse pregnancy outcomes was evaluated by the calculation of likelihood ratios. The study complied with the Declaration of Helsinki. RESULTS: Significant differences were found between pregnancy outcomes of BANA-negative and BANA-positive mothers (p<0.0001). BANA showed sensitivity and negative predictive values of 87% and 91%; 75% and 78%; 87% and 94% in detecting low birth weight, preterm delivery, and preterm low birth weight delivery respectively. CONCLUSION: This study confirms that BANA may indicate the need for periodontal therapy to reduce the risk of adverse pregnancy outcomes and could form part of the routine antenatal examination.en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.identifier.citationTurton, M. S. (2017). A simple point of care test can indicate the need for periodontal therapy to reduce the risk for adverse pregnancy outcomes in mothers attending antenatal clinics. Biomarkers, 6: 1-7en_US
dc.identifier.issn1366-5804
dc.identifier.urihttp://hdl.handle.net/10566/3137
dc.identifier.urihttp://dx.doi.org/10.1080/1354750X.2017.1334151
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherTaylor & Francis Groupen_US
dc.rights2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/Licenses/by-nc-nd/ 4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
dc.status.ispeerreviewedTRUE
dc.subjectBANAen_US
dc.subjectLow birth weighten_US
dc.subjectPreterm birthen_US
dc.subjectPregnancy-associated periodontal diseaseen_US
dc.titleA simple point of care test can indicate the need for periodontal therapy to reduce the risk for adverse pregnancy outcomes in mothers attending antenatal clinicsen_US
dc.typeArticleen_US

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