Indium nanoparticulate-modified polyanilino-co-4-aminobenzoic acid amperometric sensor for the detection of lapatinib, a breast cancer drug.
| dc.contributor.advisor | Ajayi, Rachel F. | |
| dc.contributor.author | January, Jaymi Leigh | |
| dc.date.accessioned | 2022-05-17T07:25:07Z | |
| dc.date.accessioned | 2024-05-09T10:50:03Z | |
| dc.date.available | 2024-05-09T10:50:03Z | |
| dc.date.issued | 2022 | |
| dc.description | >Magister Scientiae - MSc | en_US |
| dc.description.abstract | Lapatinib is a highly prescribed drug used in combination with other drugs to treat breast cancer. Due to drug toxicity-related side effects experienced by some patients, there is need to determine appropriate dosage for patients. A novel nanobiosensor for the determination of the biotransformation of a cancer drug (LAPA) was constructed with a co-polymer, poly(anilino-co-4-aminobenzoic acid) {poly(ANI-co-4-ABA)} coupled to ground coffee extract-based, green-synthesized indium nanoparticles (InNPs) to which cytochrome P450-3A4 (CYP3A4) enzyme was additionally attached onto a glassy carbon electrode. Polyaniline (PANI), 4-ABA, indium nanoparticles (InNPs), poly(ANI-co-4-ABA) and poly(ANI-co-4-ABA)/InNPs were synthesized and used as sensor materials. The x-ray diffraction (XRD) analysis indicated crystallinity (average crystallite size of 27.31 nm) and gave a sharp peak at 21.40 (211) that is indexed to indium metal. | en_US |
| dc.description.embargo | 2025 | |
| dc.identifier.uri | https://hdl.handle.net/10566/14466 | |
| dc.language.iso | en | en_US |
| dc.publisher | University of the Western Cape | en_US |
| dc.rights.holder | University of the Western Cape | en_US |
| dc.subject | Anti-cancer drug | en_US |
| dc.subject | Breast cancer | en_US |
| dc.subject | pulse voltammetry Green synthesis | en_US |
| dc.subject | Indium nanoparticles | en_US |
| dc.subject | Biosensor | en_US |
| dc.title | Indium nanoparticulate-modified polyanilino-co-4-aminobenzoic acid amperometric sensor for the detection of lapatinib, a breast cancer drug. | en_US |