PICSI vs. MACS for abnormal sperm DNA fragmentation ICSI cases: A prospective randomized trial

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dc.contributor.authorHenkel, Ralf
dc.contributor.authorHasanen, Eman
dc.contributor.authorElqusi, Khaled
dc.date.accessioned2021-01-05T12:55:48Z
dc.date.available2021-01-05T12:55:48Z
dc.date.issued2020
dc.description.abstractPurpose: To know which sperm selection technique, physiological intracytoplasmic sperm injection (PICSI) or magnetic-activated cell sorting (MACS), is better for the selection of sperm with abnormal sperm DNA fragmentation (SDF) in patients undergoing intracytoplasmic sperm injection (ICSI). Methods: A prospective randomized trial included 413 ICSI cases with abnormal SDF (> 20.3%) by TUNEL assay. Patients with at least 1 million total progressive motile sperm count were randomized to PICSI or MACS groups on the day of ICSI. PICSI depends on the hyaluronan binding of better SDF sperm where individual sperm was selected, while MACS selects non-apoptotic sperm population using Annexin V magnetic beads. All pre-implantation embryogenic parameters were observed and the main outcome was the ongoing pregnancy rate. Results: There were no significant differences between patients allocated to PICSI and MACS in the studied parameters including pre-implantation embryological data, implantation, clinical pregnancy, and ongoing pregnancy rates. Meanwhile, sub-analysis according to the female age has shown that female patients with less than 30 years of age in the MACS group had significantly higher good-quality blastocyst, clinical pregnancy, and ongoing pregnancy rates than the PICSI group.en_US
dc.identifier.citationHenkel, R. et al (2020). PICSI vs. MACS for abnormal sperm DNA fragmentation ICSI cases: A prospective randomized trial. Journal of Assisted Reproduction and Genetics ,37(10), 2605-2613en_US
dc.identifier.issn1058-0468
dc.identifier.urihttps://doi.org/10.1007/s10815-020-01913-4
dc.identifier.urihttp://hdl.handle.net/10566/5561
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectPICSIen_US
dc.subjectMACSen_US
dc.subjectSperm selectionen_US
dc.subjectSperm DNA fragmentationen_US
dc.subjectICSIen_US
dc.titlePICSI vs. MACS for abnormal sperm DNA fragmentation ICSI cases: A prospective randomized trialen_US
dc.typeArticleen_US

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