The effects of in utero exposure to teratogens on organ size: A prospective paediatric study
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Date
2021
Authors
Journal Title
Journal ISSN
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Publisher
Cambridge University Press
Abstract
In low-income countries, prospective data on combined effects of in utero teratogen exposure
are lacking and necessitates new research. The aim of the present study was to explore the effect
of in utero teratogen exposure on the size of the kidneys and pancreas 5 years after birth in a
low-income paediatric population. Data was collected from 500 mother–child pairs from a lowincome setting. Anthropometric measurements included body weight, (BW) body height, midupper arm and waist circumference (WC). Clinical measurements included blood pressure
(BP), mean arterial pressure and heart rate. Ultrasound measurements included pancreas,
and kidney measurements at age 5 years. The main outcome of interest was the effect of maternal smoking and alcohol consumption on ultrasound measurements of organ size at age 5 years.
Description
Keywords
Body mass index (BMI), Alcohol, Nicotine, Paediatrics, Bioscience
Citation
De Smidt, J. et al. (2021). The effects of in utero exposure to teratogens on organ size: A prospective paediatric study. Journal of Developmental Origins of Health and Disease, 12(5), 748 - 757. https://doi.org/10.1017/S2040174420001002