The effects of in utero exposure to teratogens on organ size: A prospective paediatric study

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Date

2021

Journal Title

Journal ISSN

Volume Title

Publisher

Cambridge University Press

Abstract

In low-income countries, prospective data on combined effects of in utero teratogen exposure are lacking and necessitates new research. The aim of the present study was to explore the effect of in utero teratogen exposure on the size of the kidneys and pancreas 5 years after birth in a low-income paediatric population. Data was collected from 500 mother–child pairs from a lowincome setting. Anthropometric measurements included body weight, (BW) body height, midupper arm and waist circumference (WC). Clinical measurements included blood pressure (BP), mean arterial pressure and heart rate. Ultrasound measurements included pancreas, and kidney measurements at age 5 years. The main outcome of interest was the effect of maternal smoking and alcohol consumption on ultrasound measurements of organ size at age 5 years.

Description

Keywords

Body mass index (BMI), Alcohol, Nicotine, Paediatrics, Bioscience

Citation

De Smidt, J. et al. (2021). The effects of in utero exposure to teratogens on organ size: A prospective paediatric study. Journal of Developmental Origins of Health and Disease, 12(5), 748 - 757. https://doi.org/10.1017/S2040174420001002