"Development and implementation of ontology-based systems for mammalian gene expression profiling"

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dc.contributor.advisorHide, Winston
dc.contributor.authorKruger, Adele
dc.date.accessioned2023-06-02T09:35:36Z
dc.date.accessioned2024-05-17T07:57:58Z
dc.date.available2023-06-02T09:35:36Z
dc.date.available2024-05-17T07:57:58Z
dc.date.issued2009
dc.descriptionPhilosophiae Doctor - PhDen_US
dc.description.abstractThe use of ontologies in the mapping of gene expression events provides an effective and comparable method to determine the expression profile of an entire genome across a large collection of experiments derived from different expression sources. In this dissertation I describe the development of the developmental human and mouse e VOC ontologies and demonstrate the ontologies by identifying genes showing a bias for developmental brain expression in human and mouse, identifying transcription factor complexes, and exploring the mouse orthologs of human cancer/testis genes. Model organisms represents fundamental aspects of mammal biology phenomena between model organism is complex and it is to be the meaningful, a simplified representation can be a powerful means for comparison illustrated here in two ways. Firstly, the ontologies have been used to illustrate methods to determine clusters of genes showing tissue-restricted expression in humans. The identification of tissue-restricted genes within an organism serves as an indication of the finetuning in the regulation of gene expression in a given tissue. Secondly, due to the differences in human and mouse gene expression on a temporal and spatial level, the ontologies were used to identify mouse orthologs of human cancer/testis genes showing cancer/testis characteristics. With the use of model systems such as mouse in the development of gene-targeted drugs in the treatment of disease, it is important to establish that the expression characteristics and profiles of a drug target in the model system is representative of the characteristics of the target in the system for which it is intended.en_US
dc.identifier.urihttps://hdl.handle.net/10566/15291
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectOntologyen_US
dc.subjectExpression vocabularyen_US
dc.subjectGene expressionen_US
dc.subjectCross-speciesen_US
dc.subjectcompansonen_US
dc.subjectHuman developmenten_US
dc.subjectMouse developmenten_US
dc.subjectCancer/testisen_US
dc.subjectTranscription factoren_US
dc.subjectGene regulationen_US
dc.title"Development and implementation of ontology-based systems for mammalian gene expression profiling"en_US

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Philosophiae Doctor - PhD (Bioinformatics)