Closing the HIV treatment gap for adolescents in Windhoek, Namibia: A retrospective analysis of predictors of viral non-suppression

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dc.contributor.authorMunyayi, Farai Kevin
dc.contributor.authorvan Wyk, Brian
dc.date.accessioned2023-02-06T08:04:27Z
dc.date.available2023-02-06T08:04:27Z
dc.date.issued2022
dc.description.abstractWindhoek joined the Fast-Track Cities Initiative in 2017 to optimize HIV service delivery for adolescents, promoting adherence and sustaining viral suppression. Recent surveys and programmatic data show that the treatment gap remains greatest among children and adolescents living with HIV. A retrospective cohort analysis of adolescents living with HIV (ALHIV) receiving antiretroviral therapy (ART) at Windhoek healthcare facilities was conducted. Routine clinical data were extracted from the electronic Patient Monitoring System (ePMS). The SPSS statistical package was used to determine viral non-suppression and perform inferential statistics. 695 ALHIV were analysed with median age of 16 years (IQR = 13–18). Viral non-suppression at 1000 copies/mL threshold was 12%. Viral non-suppression was associated with age at ART initiation, duration on ART, current ART regimen and WHO Clinical Stage. In multivariate analysis, longer duration on ART was a protective factor for viral non-suppression (13–24 months vs. >24 months: aOR = 8.92, 95% CI 2.60–30.61), while being on third line regimen (vs. first line) was protective against viral non-suppression (aOR = 0.11, 95% CI 0.03–0.49). A significant treatment gap is evident for ALHIV with high viral non-suppression levels. Interventions are required to counter treatment fatigue to keep adolescents engaged in ART, and timely switching to rescue regimens for failing adolescents.en_US
dc.identifier.citationMunyayi, F. K., & van Wyk, B. (2022). Closing the HIV treatment gap for adolescents in Windhoek, Namibia: A retrospective analysis of predictors of viral non-suppression. International Journal of Environmental Research and Public Health, 19(22), 14710. https://doi.org/10.3390/ijerph192214710en_US
dc.identifier.issn1660-4601
dc.identifier.urihttps://doi.org/10.3390/ijerph192214710
dc.identifier.urihttp://hdl.handle.net/10566/8351
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectPublic healthen_US
dc.subjectHIVen_US
dc.subjectAdolescentsen_US
dc.subjectPatienten_US
dc.subjectNamibiaen_US
dc.titleClosing the HIV treatment gap for adolescents in Windhoek, Namibia: A retrospective analysis of predictors of viral non-suppressionen_US
dc.typeArticleen_US

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