The effect of n'n-bis(dichloroacetyl)-1,8- octamethylenbdtamtne (wrn 18446) on the testis, epididymis, sperm and fertility of male cba micethe effect of n'n-bis(dichloroacetyl)-1,8- octamethylenbdtamtne (wrn 18446) on the testis, epididymis, sperm and fertility
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Date
1999
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of Western Cape
Abstract
Although the modern era of contraception has focused attention on the female, research into
male contraception is continuing on several fronts. Despite the widespread use of
premature withdrawal, the condom and vasectomy, there is no acceptable drug for
controlling fertility in the male. Research and developments to suppress the sperm
production, inhibit the maturation of sperrn, and block sperrn transport are under
investigation. Thus, a strong demand exists for a safe, reversible and effective male
contraceptive. A compoundN'N-bis(dichloroacetyl)- 1,8-octamethylenediamine, commonly
known as WIN 18446 used in the treatment of amebiasis was found to possess antispermatogenic
activity. WIN 18446 (WIN), the most potent of the
bis(dichloroacetyl)diamines and one of the least active amoebicidal agents was shown to
exert a specific effect on the testes while the Leydig cells were unaffected. Full recovery
of spermatogenesis is established upon the withdrawal of WIN. One drawback associated
with this compound was that the human consumption of alcohol induced an antabuse effect
Description
Magister Scientiae (Biodiversity and Conservation Biology)
Keywords
Contraception, Win 18446, Antispermatogenic, DNC and mxALH, N'N-bis(dichloroacetyl)