Novel South African rare actinomycete kribbella speibonae Strain SK5: A prolific producer of hydroxamate siderophores including new dehydroxylated congeners

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Date

2020

Journal Title

Journal ISSN

Volume Title

Publisher

MDPI

Abstract

In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners. Two new analogues, dehydroxylated desferrioxamines, speibonoxamine 1 and desoxy-desferrioxamine D1 2, have been isolated, together with four known hydroxamates, desferrioxamine D1 3, desferrioxamine B 4, desoxy-nocardamine 5 and nocardamine 6, and a diketopiperazine (DKP) 7. The structures of 1–7 were characterized by the analysis of HRESIMS and 1D and 2D NMR data, as well as by comparison with the relevant literature.

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Keywords

Kribbella, Speibonoxamine, Siderophore, Hydroxamate, Molecular networking

Citation

Beukes, D. R. et al. (2020). Novel South African rare actinomycete kribbella speibonae Strain SK5: A prolific producer of hydroxamate siderophores including new dehydroxylated congeners. Molecules ,25(13),2979