Proprotein convertase subtilisin/kexin type 9 genetic screening using the vervet (Chlorocebus aethiops) model

Simple item page
dc.contributor.authorObikeze, Kenechukwu
dc.contributor.authorNgqaneka, Thobile
dc.contributor.authorMagwebu, Zandisiwe E
dc.contributor.authorChauke, Chesa G
dc.date.accessioned2023-04-12T08:06:51Z
dc.date.available2023-04-12T08:06:51Z
dc.date.issued2022
dc.description.abstractBackground: The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene has come to prominence due to its reported function in the clearance of low-density li-poprotein cholesterol. The vervet monkey (Chlorocebus aethiops) was utilized to study the genetics of PCSK9 gene. Method: Sixteen vervet monkeys were selected to screen for possible PCSK9 poly-morphisms and to determine gene expression. Results: Four PCSK9 sequence variants (T112T, R148S, H177N and G635G) were identified and three of these variants (H177N, R148S, and G635G) were categorized as loss of function mutations. A decline in gene expression levels was also observed in animals harboring these three variants. Although the selected variants might have affected the level of gene expression in the selected animals, individual variation was also noticed in some of these individuals with the G635G variant. Conclusion: Based on the findings obtained from this study, it is suggestive that the activity of PCSK9 was hindereden_US
dc.identifier.citationNgqaneka, T., Obikeze, K., Magwebu, Z.E. and Chauke, C.G., 2023. Proprotein convertase subtilisin/kexin type 9 genetic screening using the vervet (Chlorocebus aethiops) model. Journal of Medical Primatology, 52(1), pp.45-52.en_US
dc.identifier.urihttps://doi.org/10.1111/jmp.12623
dc.identifier.urihttp://hdl.handle.net/10566/8737
dc.language.isoenen_US
dc.publisherJournal of Medical Primatologyen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectlow-density lipoprotein cholesterolen_US
dc.subjectsequence variantsen_US
dc.subjectvervet monkeyen_US
dc.subjectproprotein convertase subtilisinen_US
dc.titleProprotein convertase subtilisin/kexin type 9 genetic screening using the vervet (Chlorocebus aethiops) modelen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ngqaneka_Proprotein convertase subtilisin_2022.pdf
Size:
382.67 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Articles (School of Pharmacy)