Genetic characterisation of Campylobacter concisus: Strategies for improved genomospecies discrimination

Simple item page
dc.contributor.authorLastovica, A.J
dc.contributor.authorCornelius, A.J
dc.contributor.authorHuq, M
dc.date.accessioned2021-04-15T09:48:23Z
dc.date.available2021-04-15T09:48:23Z
dc.date.issued2021
dc.description.abstractAlthough at least two genetically distinct groups, or genomospecies, have been well documented for Campylobacter concisus, no phenotype has yet been identified for their differentiation and thus formal description as separate species. C. concisus has been isolated from a variety of sites in the human body, including saliva and stool samples from both healthy and diarrhoeic individuals. We evaluated the ability of a range of whole genome-based tools to distinguish between the two C. concisus genomospecies (GS) using a collection of 190 C. concisus genomes. Nine genomes from related Campylobacter species were included in some analyses to provide context. Analyses incorporating sequence analysis of multiple ribosomal genes generated similar levels of C. concisus GS discrimination as genome-wide comparisons. The C. concisus genomes formed two groups; GS1 represented by ATCC 33237T and GS2 by CCUG 19995. The two C. concisus GS were separated from the nine genomes of related species. GS1 and GS2 also differed in G+C content with medians of 37.56% and 39.51%, respectively.en_US
dc.identifier.citationLastovica, A.J. et al. (2021). Genetic characterisation of Campylobacter concisus: Strategies for improved genomospecies discrimination. Systematic and Applied Microbiology ,44(3),126187en_US
dc.identifier.issn0723-2020
dc.identifier.uri10.1016/j.syapm.2021.126187
dc.identifier.urihttp://hdl.handle.net/10566/6046
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectAverage nucleotide identityen_US
dc.subjectClusters of orthologous groups analysisen_US
dc.subjectComparative genomic analysisen_US
dc.subjectGenome BLAST distance phylogenyen_US
dc.subjectLarge scale BLAST score ratioen_US
dc.subjectRibosomal RNA operonen_US
dc.titleGenetic characterisation of Campylobacter concisus: Strategies for improved genomospecies discriminationen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S0723202021000102-main.pdf
Size:
2.69 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Articles (Biotechnology)