Challenges of biobanking in South Africa to facilitate indigenous research in an environment burdened with human immunodeficiency virus, tuberculosis, and emerging non-communicable diseases

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dc.contributor.authorAbayomi, Akin
dc.contributor.authorChristoffels, Alan
dc.contributor.authorGrewal, Ravnit
dc.contributor.authorKaram, Locunda A.
dc.contributor.authorRossouw, Catherine
dc.contributor.authorStaunton, Ciara
dc.contributor.authorSwanepoel, Carmen
dc.contributor.authorvan Rooyen, Beverley
dc.date.accessioned2018-01-29T09:24:00Z
dc.date.available2018-01-29T09:24:00Z
dc.date.issued2013
dc.description.abstractThe high burden of infectious diseases and the growing problem of noncommunicable and metabolic disease syndromes in South Africa (SA) forces a more focused research approach to facilitate cutting-edge scientific growth and public health development. Increased SA research on these diseases and syndromes and the collection of associated biospecimens has ensured a plethora of biobanks created by individuals, albeit without the foresight of prospective and collective use by other local and international researchers. As the need for access to high-quality specimens in statistically relevant numbers has increased, so has the necessity for the development of national human biobanks in SA and across the Continent. The prospects of achieving sustainable centralized biobanks are still an emerging and evolving concept, primarily and recently driven by the launch of the H3Africa consortium, which includes the development of harmonized and standardized biobanking operating procedures. This process is hindered by a myriad of complex societal considerations and ethico-legal challenges. Efforts to consolidate and standardize biological sample collections are further compromised by the lack of full appreciation by national stakeholders of the biological value inherent in these collections, and the availability of high quality human samples with well-annotated data for future scientific research and development. Inadequate or nonexistent legislative structures that specifically regulate the storage, use, dispersal, and disposal of human biological samples are common phenomena and pose further challenges. Furthermore, concerns relating to consent for unspecific future uses, as well as access to information and data protection, are all new paradigms that require further consideration and public engagement. This article reviews important fundamental issues such as governance, ethics, infrastructure, and bioinformatics that are important foundational prerequisites for the establishment and evolution of successful human biobanking in South Africa.en_US
dc.description.accreditationWeb of Science
dc.identifier.citationAbayomi, A. et al. (2013). Challenges of biobanking in South Africa to facilitate indigenous research in an environment burdened with human immunodeficiency virus, tuberculosis, and emerging non-communicable diseases. Biopreservation and Biobanking, 11(6): 347 – 354en_US
dc.identifier.issn1947-5535
dc.identifier.urihttp://dx.doi.org/10.1089/bio.2013.0049
dc.identifier.urihttp://hdl.handle.net/10566/3429
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherMary Ann Liebert, Inc.en_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/10.1089/bio.2013.0049
dc.status.ispeerreviewedTRUE
dc.subjectHIVen_US
dc.subjectTuberculosisen_US
dc.subjectNon-communicable diseasesen_US
dc.subjectHigh quality specimensen_US
dc.subjectBiobankingen_US
dc.titleChallenges of biobanking in South Africa to facilitate indigenous research in an environment burdened with human immunodeficiency virus, tuberculosis, and emerging non-communicable diseasesen_US
dc.typeArticleen_US

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